495-32-9
Chemical Structure
Nodakenetin
- CAS No.: 495-32-9
- Formula:C14H14O4
- Molecular Weight:246.26
IUPAC Name: (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one
InChIKey: FWYSBEAFFPBAQU-GFCCVEGCSA-N
SMILES: O=C1C=CC2=CC3=C(O[C@@H](C(C)(O)C)C3)C=C2O1
Biological Activity: Nodakenetin is an orally active Wnt/β-catenin pathway activator. Nodakenetin reduces the level of DKK1, and upregulates c-Myc, cyclin D1 and survivin. Nodakenetin induces osteoprogenitor cell differentiation, upregulates bone formation biomarkers and prevents bone microstructure degeneration. Nodakenetin induces irritant skin reactions. Nodakenetin improves bone microstructure and histomorphometric parameters in osteoporotic mouse models. Nodakenetin can be used for osteoporosis-related research[1][2][3].
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Nodakenetin | 99.66% | Nodakenetin is an orally active Wnt/β-catenin pathway activator. Nodakenetin reduces the level of DKK1, and upregulates c-Myc, cyclin D1 and survivin. Nodakenetin induces osteoprogenitor cell differentiation, upregulates bone formation biomarkers and prevents bone microstructure degeneration. Nodakenetin induces irritant skin reactions. Nodakenetin improves bone microstructure and histomorphometric parameters in osteoporotic mouse models. Nodakenetin can be used for osteoporosis-related research. | ||||||||||||||||||||
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- [1]. Jeong EJ, et al. Antiosteoporotic activity of nodakenetin, a coumarin compound from Angelica decursiva, by activation of the Wnt/β-catenin signaling pathway. J Tradit Complement Med. 2024 Nov 5;15(7):736-744. [Content Brief]
- [2]. Saeed MA, et al. Irritant and cytotoxic coumarins from Angelica glauca Edgew roots. J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):49-58. [Content Brief]
- [3]. Zhao D, et al. In vitro antioxidant and anti-inflammatory activities of Angelica decursiva. Archives of pharmacal research. 2012 Jan;35(1):179-92. [Content Brief]
Keywords
