499-80-9
499-80-9
Chemical Structure
2,4-PDCA
- CAS No.: 499-80-9
- Formula:C7H5NO4
- Molecular Weight:167.12
IUPAC Name: pyridine-2,4-dicarboxylic acid
InChIKey: MJIVRKPEXXHNJT-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC(C(O)=O)=C1)O
Biological Activity: 2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2,4-PDCA | 99.82% | 2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-W0125232,5-Pyridinedicarboxylic acid -
Similarity Score 0.89
HY-100807Quinolinic acid -
Similarity Score 0.89
HY-100807S1Quinolinic acid-13C7 -
Similarity Score 0.89
HY-W654331Quinolinic acid-13C3,15N -
Similarity Score 0.87
HY-Y1024Pyridine-2,6-dicarboxylic acid -
Similarity Score 0.86
HY-W002000Pyridine-3,5-dicarboxylic acid -
Similarity Score 0.86
HY-W052935Pyrimidine-4,6-dicarboxylic acid -
Similarity Score 0.86
HY-Y18363,4-Pyridinedicarboxylic acid -
Similarity Score 0.85
HY-21323Isophthalic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804. [Content Brief]
- [2]. Gómez-Álvarez H, et al. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour Technol. 2022 Feb;346:126638. [Content Brief]
- [3]. Hanauske-Abel HM. Prolyl 4-hydroxylase, a target enzyme for drug development. Design of suppressive agents and the in vitro effects of inhibitors and proinhibitors. J Hepatol. 1991;13 Suppl 3:S8-15; discussion S16. [Content Brief]
