499-80-9
499-80-9
Chemical Structure
2,4-PDCA
- CAS No.: 499-80-9
- Formula:C7H5NO4
- Molecular Weight:167.12
IUPAC Name: pyridine-2,4-dicarboxylic acid
InChIKey: MJIVRKPEXXHNJT-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC(C(O)=O)=C1)O
Biological Activity: 2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].
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2,4-PDCA | 99.82% | 2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics. | ||||||||||||||||||||
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References
- [1]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804. [Content Brief]
- [2]. Gómez-Álvarez H, et al. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour Technol. 2022 Feb;346:126638. [Content Brief]
- [3]. Hanauske-Abel HM. Prolyl 4-hydroxylase, a target enzyme for drug development. Design of suppressive agents and the in vitro effects of inhibitors and proinhibitors. J Hepatol. 1991;13 Suppl 3:S8-15; discussion S16. [Content Brief]
