519-95-9
Chemical Structure
Florantyrone
Synonym(s): Zanchol
- CAS No.: 519-95-9
- Formula:C20H14O3
- Molecular Weight:302.32
IUPAC Name: 4-(fluoranthen-8-yl)-4-oxobutanoic acid
InChIKey: QOBAOSCOLAGPKI-UHFFFAOYSA-N
SMILES: O=C(CCC(C1=CC2=C(C=C1)C3=CC=CC4=CC=CC2=C34)=O)O
Biological Activity: Florantyrone (Zanchol) is a bile-promoting agent. Florantyrone increases the volume of bile rather than the content of bile acids. Zanchol can stimulate the synthesis of cholesterol in the liver, significantly raising the plasma cholesterol level, increasing the weight of the liver, but has no significant effect on the synthesis of cholesterol in the intestine. Florantyrone can be used in research on biliary motility disorders[1][2][3].
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Florantyrone | Florantyrone (Zanchol) is a bile-promoting agent. Florantyrone increases the volume of bile rather than the content of bile acids. Zanchol can stimulate the synthesis of cholesterol in the liver, significantly raising the plasma cholesterol level, increasing the weight of the liver, but has no significant effect on the synthesis of cholesterol in the intestine. Florantyrone can be used in research on biliary motility disorders. | |||||||||||||||||||||
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- [1]. MEEROFF M. Acción hidrocolerética de la florantirona [Hydrocholeretic action of florantyrone]. Prensa Med Argent. 1958 Mar 21;45(12):1272-6. Spanish. [Content Brief]
- [2]. Raicht RF, et al. Effect of a hydrocholeretic agent (Zanchol) on sterol metabolism in rats. Gastroenterology. 1977 Mar;72(3):507-9. [Content Brief]
- [3]. Turley SD, Dietschy JM. Effects of clofibrate, cholestyramine, zanchol, probucol, and AOMA feeding on hepatic and intestinal cholesterol metabolism and on biliary lipid secretion in the rat. J Cardiovasc Pharmacol. 1980;2(3):281-97. [Content Brief]
Keywords
