521-65-3
Chemical Structure
Swerchirin
- CAS No.: 521-65-3
- Formula:C15H12O6
- Molecular Weight:288.25
IUPAC Name: 1,8-dihydroxy-3,5-dimethoxy-9H-xanthen-9-one
InChIKey: GNSHHHWDGOHNPC-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=C(C=C2O)OC)OC3=C1C(O)=CC=C3OC
Biological Activity: Swerchirin is an orally active, plant-derived xanthone that acts as an inhibitor of the Raf/MEK/ERK signaling pathway. Swerchirin downregulates the expression of phosphorylated MEK and phosphorylated ERK, induces mitochondrial apoptosis and cell cycle arrest, regulates Bcl-2 family proteins, triggers cytochrome c release, activates caspases, and drives PARP cleavage. Swerchirin reduces blood glucose levels in rat models under fasting, fed, glucose-loaded conditions, and following treatment with Tolbutamide (HY-B0401). Swerchirin can be used in research related to ovarian cancer, liver injury, and diabetes[1][2][3].
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Swerchirin | Swerchirin is an orally active, plant-derived xanthone that acts as an inhibitor of the Raf/MEK/ERK signaling pathway. Swerchirin downregulates the expression of phosphorylated MEK and phosphorylated ERK, induces mitochondrial apoptosis and cell cycle arrest, regulates Bcl-2 family proteins, triggers cytochrome c release, activates caspases, and drives PARP cleavage. Swerchirin reduces blood glucose levels in rat models under fasting, fed, glucose-loaded conditions, and following treatment with Tolbutamide (HY-B0401). Swerchirin can be used in research related to ovarian cancer, liver injury, and diabetes. | |||||||||||||||||||||
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- [1]. Luo L, et al. Swerchirin exerts anticancer activity on SKOV3 human ovartian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2021;26(1):288.
- [2]. Hajimehdipoor H, et al. Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice. The Journal of pharmacy and pharmacology. 2006 Feb;58(2):277-80.
- [3]. Bajpai MB, et al. Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Planta medica. 1991 Apr;57(2):102-4.
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