5335-95-5
5335-95-5
Chemical Structure
NSC 1008
- CAS No.: 5335-95-5
- Formula:C22H18N2O
- Molecular Weight:326.40
IUPAC Name: 7-(phenyl(phenylamino)methyl)quinolin-8-ol
InChIKey: OTNAVATYWOEDMK-UHFFFAOYSA-N
SMILES: OC=1C2=NC=CC=C2C=CC1C(NC=3C=CC=CC3)C=4C=CC=CC4
Biological Activity: NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 μM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer[1].
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NSC 1008 | NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 μM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer. | |||||||||||||||||||||
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