2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. NSC 1008

NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 μM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer.

For research use only. We do not sell to patients.

NSC 1008

NSC 1008 Chemical Structure

CAS No. : 5335-95-5

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NSC 1008 Related Antibodies

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Description

NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 μM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer[1].

In Vitro

NSC 1008 (compound 2) inhibits human Rce1 activity (IC50 = 8.9 μM)[1].
NSC 1008 (25 µM; 20 hours) exhibits low toxicity in HCT-116 cells[1].
NSC 1008 (25 µM; 20 hours) induces mislocalization of EGFP-H-Ras, EGFP-N-Ras, and EGFP-K-Ras4b in HCT-116 cells[1].
NSC 1008 (10-50 µM) demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 1008 Related Antibodies

Cell Viability Assay[1]

Cell Line: HCT-116 human colon carcinoma cells
Concentration: 25 μM
Incubation Time: 20-hour treatment; 4-hour reagent incubation
Result: Caused minimal cell death (less than 10%) compared to DMSO-treated and untreated cells.
Molecular Weight

326.40

Formula

C22H18N2O
CAS No.
SMILES

OC=1C2=NC=CC=C2C=CC1C(NC=3C=CC=CC3)C=4C=CC=CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC 1008 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 10085335-95-5NSC1008NSC-1008Rasplasma membraneHCT-116 cellschemical biology toolsEGFP-K-Ras4bEGFP-RasHsSte24Ras functionEGFP-N-RasRas converting enzyme 1cancerFTaseEGFP-H-RasRce1cancer cellsInhibitorinhibitorinhibit

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