543734-50-5
543734-50-5
Chemical Structure
NHE3-IN-3
- CAS No.: 543734-50-5
- Formula:C16H16Cl2N2O2S
- Molecular Weight:371.28
IUPAC Name: 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzenesulfonamide
InChIKey: UNNPAFDYRLETBW-UHFFFAOYSA-N
SMILES: CN1CC2=C(C(C1)C3=CC(S(N)(=O)=O)=CC=C3)C=C(C=C2Cl)Cl
Biological Activity: NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].
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NHE3-IN-3 | NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats. | |||||||||||||||||||||
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