548-40-3
Chemical Structure
Oxyacanthine
- No. CAS: 548-40-3
- Formula:C37H40N2O6
- Molecular Weight:608.72
IUPAC Name: (11R,31S)-16,36,37-trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,4),7(1,3)-dibenzenacyclooctaphan-76-ol
InChIKey: HGNHIFJNOKGSKI-WDYNHAJCSA-N
SMILES: COC1=C(OC(C=C2[C@@]3([H])CC4=CC=C5O)=C(C=C2CCN3C)OC)C([C@]6([H])CC7=CC=C(OC5=C4)C=C7)=C(CCN6C)C=C1OC
Biological Activity: Oxyacanthine is a bisbenzylisoquinoline alkaloid and anti-inflammatory agent. Oxyacanthine exists in plants such as Berberis oblonga, Berberis vulgaris and Berberis aquifolium. Oxyacanthine inhibits the gene expression of pro-inflammatory cytokines IL-6 and IL-1β. Oxyacanthine exhibits anti-SARS-CoV-2 activity. Oxyacanthine is applicable to research related to COVID-19[1][2].
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Oxyacanthine | 98.07% | Oxyacanthine is a bisbenzylisoquinoline alkaloid and anti-inflammatory agent. Oxyacanthine exists in plants such as Berberis oblonga, Berberis vulgaris and Berberis aquifolium. Oxyacanthine inhibits the gene expression of pro-inflammatory cytokines IL-6 and IL-1β. Oxyacanthine exhibits anti-SARS-CoV-2 activity. Oxyacanthine is applicable to research related to COVID-19. | ||||||||||||||||||||
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References
- [1]. Xiang L, et al. Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates. Journal of natural products. 2025 Dec 26;88(12):2947-2959. [Content Brief]
- [2]. Lu J, et al. Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity. Bioorganic & medicinal chemistry letters. 2024 Nov 15;113:129951. [Content Brief]
