55242-55-2
Chemical Structure
Propentofylline
Synonym(s): HWA 285
- CAS No.: 55242-55-2
- Formula:C15H22N4O3
- Molecular Weight:306.36
IUPAC Name: 3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: RBQOQRRFDPXAGN-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1CCCCC(C)=O)=O)N=CN2CCC
Biological Activity: Propentofylline (HWA 285) is an orally active, blood-brain barrier-penetrant phosphodiesterase inhibitor, with an IC50 of 20 μM for cGMP-stimulated PDE II. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Propentofylline | 99.88% | Propentofylline (HWA 285) is an orally active, blood-brain barrier-penetrant phosphodiesterase inhibitor, with an IC50 of 20 μM for cGMP-stimulated PDE II. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders. | ||||||||||||||||||||
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Propentofylline-d6 | Propentofylline-d6 (HWA 285-d6) is the d6-labeled Propentofylline (HY-107203). Propentofylline (HWA 285) is an orally active, blood-brain barrier-penetrant phosphodiesterase inhibitor, with an IC50 of 20 μM for cGMP-stimulated PDE II. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders. | |||||||||||||||||||||
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Similarity Score 0.88
HY-B0715Pentoxifylline -
Similarity Score 0.85
HY-U00142A-802715 -
Similarity Score 0.85
HY-114531Lomifylline -
Similarity Score 0.81
HY-B0715S3Pentoxifylline-d3 -
Similarity Score 0.81
HY-W273690Pentifylline -
Similarity Score 0.80
HY-130786Denbufylline -
Similarity Score 0.78
HY-171128PTX-M -
Similarity Score 0.77
HY-N97571-(3-Carboxypropyl)-3,7-dimethylxanthine -
Similarity Score 0.77
HY-109854(S)-Lisofylline -
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References
- [1]. Noble S, et al. Propentofylline. CNS Drugs. 1997 Sep;8(3):257-264.
- [2]. Parkinson FE, et al. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen Pharmacol. 1994 Oct;25(6):1053-8. [Content Brief]
- [3]. Goto M, et al. Effects of propentofylline on disorder of learning and memory in rodents. Jpn J Pharmacol. 1987 Nov;45(3):373-8. [Content Brief]
- [4]. Rother M, et al. Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials. Dement Geriatr Cogn Disord. 1998;9 Suppl 1:36-43. [Content Brief]
