55321-99-8
55321-99-8
Chemical Structure
T-1105
- CAS No.: 55321-99-8
- Formula:C5H5N3O2
- Molecular Weight:139.11
IUPAC Name: 3-hydroxypyrazine-2-carboxamide
InChIKey: SZPBAPFUXAADQV-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CN=C1O)N
Biological Activity: T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase[1][2].
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T-1105 | 99.74% | T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase. | ||||||||||||||||||||
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References
- [1]. Huchting J, et al. Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res. 2019 Jul;167:1-5. [Content Brief]
- [2]. Furuta Y, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009 Jun;82(3):95-102. [Content Brief]
Keywords
