55321-99-8
55321-99-8
Chemical Structure
T-1105
- CAS No.: 55321-99-8
- Formula:C5H5N3O2
- Molecular Weight:139.11
IUPAC Name: 3-hydroxypyrazine-2-carboxamide
InChIKey: SZPBAPFUXAADQV-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CN=C1O)N
Biological Activity: T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase[1][2].
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T-1105 | 99.96% | T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-Y17023-Amino-2-pyrazinecarboxylic acid -
Similarity Score 0.80
HY-B0271Pyrazinamide -
Similarity Score 0.77
HY-106048Bredinin aglycone -
Similarity Score 0.75
HY-76210R5-Hydroxypyrazine-2-Carboxylic Acid (Standard) -
Similarity Score 0.74
HY-W017105Pyrazine-2,3-dicarboxylic acid -
Similarity Score 0.74
HY-603462-Pyrimidinecarboxylic acid -
Similarity Score 0.73
HY-W0256165-Hydroxypyrazinecarboxamide -
Similarity Score 0.73
HY-W039157R2-Acetyl-3-ethylpyrazine (Standard) -
Similarity Score 0.73
HY-Y0030A3-Hydroxypicolinic acid, matrix substance for MALDI-MS -
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References
- [1]. Huchting J, et al. Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res. 2019 Jul;167:1-5. [Content Brief]
- [2]. Furuta Y, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009 Jun;82(3):95-102. [Content Brief]
