554403-49-5
554403-49-5
Chemical Structure
WAY-181187
Synonym(s): SAX-187
- CAS No.: 554403-49-5
- Formula:C15H13ClN4O2S2
- Molecular Weight:380.87
IUPAC Name: 2-(1-((6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethan-1-amine
InChIKey: RYBOXBBYCVOYNO-UHFFFAOYSA-N
SMILES: NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4
Biological Activity: WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
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WAY-181187 | 98.83% | WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist. | ||||||||||||||||||||
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References
- [1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]
- [2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. [Content Brief]
Keywords
