555-65-7
555-65-7
Chemical Structure
Brocresine
Synonym(s): NSD-1065
- CAS No.: 555-65-7
- Formula:C7H8BrNO2
- Molecular Weight:218.05
IUPAC Name: 5-((aminooxy)methyl)-2-bromophenol
InChIKey: QNWOSJAGFSUDFE-UHFFFAOYSA-N
SMILES: OC1=CC(CON)=CC=C1Br
Biological Activity: Brocresine (NSD-1065) is an orally active histidine decarboxylase inhibitor and inhibits the formation of histamine from histidine. Brocresine is also a L-amino acid decarboxylase inhibitor with both a peripheral and central action. Brocresine inhibits gastric secretory response to administration of exogenous gastrin[1][2].
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Brocresine | Brocresine (NSD-1065) is an orally active histidine decarboxylase inhibitor and inhibits the formation of histamine from histidine. Brocresine is also a L-amino acid decarboxylase inhibitor with both a peripheral and central action. Brocresine inhibits gastric secretory response to administration of exogenous gastrin. | |||||||||||||||||||||
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References
- [1]. Howse PM, et al. Brocresine in Parkinson's disease. Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa. J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):27-9. [Content Brief]
- [2]. Fletcher TL, et al. Effect of 4-bromo-3-hydroxybenzyloxyamine (Brocresine) on gastric secretion in pouch dogs. Proc Soc Exp Biol Med. 1969 Oct;132(1):205-11. [Content Brief]
