55903-92-9
Chemical Structure
Cucurbitacin R
- CAS No.: 55903-92-9
- Formula:C30H46O7
- Molecular Weight:518.68
IUPAC Name: (3S,8S,9R,10R,13R,14S,16S,17R)-17-((R,E)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl)-3,16-dihydroxy-4,4,9,13,14-pentamethyl-3,4,7,8,9,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2,11-dione
InChIKey: ITMUUFDDBRYVNJ-VOKXYEOFSA-N
SMILES: C[C@]12[C@@]([C@@]([C@@H](C1)O)([H])[C@@](C)(O)C(CCC(C)(O)C)=O)(CC([C@@]3([C@@]2([H])CC=C4[C@@]3([H])C[C@@H](C(C4(C)C)=O)O)C)=O)C
Biological Activity: Cucurbitacin R is an orally active anti-inflammatory agent. Cucurbitacin R is isolated from the roots of Cayaponia tayuya. Cucurbitacin R inhibits Cyclooxygenase-2. Cucurbitacin R inhibits Interleukin-6-induced STAT3 activation and cytokine production, blocks NF-κB activation, and selectively prevents NFAT nuclear translocation without affecting Calcineurin activity. Cucurbitacin R inhibits TNF-α production and Nitric-oxide synthase-2 expression. Cucurbitacin R reduces joint damage, soft tissue swelling, paw edema, ear edema, inflammatory cell infiltration, and epithelial thickness. Cucurbitacin R can be used for research on arthritis and delayed-type hypersensitivity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cucurbitacin R | 97.56% | Cucurbitacin R is an orally active anti-inflammatory agent. Cucurbitacin R is isolated from the roots of Cayaponia tayuya. Cucurbitacin R inhibits Cyclooxygenase-2. Cucurbitacin R inhibits Interleukin-6-induced STAT3 activation and cytokine production, blocks NF-κB activation, and selectively prevents NFAT nuclear translocation without affecting Calcineurin activity. Cucurbitacin R inhibits TNF-α production and Nitric-oxide synthase-2 expression. Cucurbitacin R reduces joint damage, soft tissue swelling, paw edema, ear edema, inflammatory cell infiltration, and epithelial thickness. Cucurbitacin R can be used for research on arthritis and delayed-type hypersensitivity. | ||||||||||||||||||||
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References
- [1]. Escandell JM, et al. Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. The Journal of pharmacology and experimental therapeutics. 2007 Feb;320(2):581-90.
- [2]. Escandell JM, et al. Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus. The Journal of pharmacology and experimental therapeutics. 2010 Feb;332(2):352-63.
- [3]. Recio MC, et al. Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta medica. 2004 May;70(5):414-20. [Content Brief]
