56501-26-9
56501-26-9
Chemical Structure
SP-141 hydrochloride
- CAS No.: 56501-26-9
- Formula:C34H54ClNO3
- Molecular Weight:560.25
IUPAC Name: 6,6,9-trimethyl-3-(3-methyloctan-2-yl)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-1-yl 4-(piperidin-1-yl)butanoate hydrochloride
InChIKey: PTOVAPZBPNQUQG-UHFFFAOYSA-N
SMILES: O=C(CCCN1CCCCC1)OC2=C3C(CC(C)CC4)=C4C(C)(C)OC3=CC(C(C)C(C)CCCCC)=C2.Cl
Biological Activity: SP-141 (hydrochloride) is a specific inhibitor of MDM2. SP-141 (hydrochloride) promotes MDM2 auto-ubiquitination and degradation. SP-141 (hydrochloride) might be used for the research of pancreatic cancer and breast cancer cells[1][2].
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SP-141 hydrochloride | SP-141 (hydrochloride) is a specific inhibitor of MDM2. SP-141 (hydrochloride) promotes MDM2 auto-ubiquitination and degradation. SP-141 (hydrochloride) might be used for the research of pancreatic cancer and breast cancer cells. | |||||||||||||||||||||
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References
- [1]. Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147(4):893-902.e2. [Content Brief]
- [2]. Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086. [Content Brief]
Keywords
