56583-49-4
Chemical Structure
PIT
Synonym(s): 2,2'-Pyridylisatogen tosylate
- CAS No.: 56583-49-4
- Formula:C20H16N2O5S
- Molecular Weight:396.42
IUPAC Name: 3-oxo-2-(pyridin-2-yl)-3H-indole 1-oxide 4-methylbenzenesulfonate
InChIKey: MMPTYEXNPWSTOR-UHFFFAOYSA-N
SMILES: O=C1C(C2=NC=CC=C2)=[N+]([O-])C3=C1C=CC=C3.O=S(C4=CC=C(C)C=C4)(O)=O
Biological Activity: PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma[1][2][3].
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PIT | 99.07% | PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma. | ||||||||||||||||||||
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PIT (Standard) | ≥98% | PIT (Standard) is the analytical standard of PIT (HY-108662). This product is intended for research and analytical applications. PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma. | ||||||||||||||||||||
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- [1]. Gao ZG, et al. 2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding. Biochem Pharmacol. 2004 Jul 15;68(2):231-7. [Content Brief]
- [2]. King BF, et al. Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br J Pharmacol. 1996 Mar;117(6):1111-8. [Content Brief]
- [3]. Menton K, et al. Role of spin trapping and P2Y receptor antagonism in the neuroprotective effects of 2,2'-pyridylisatogen tosylate and related compounds. Eur J Pharmacol. 2002 May 24;444(1-2):53-60. [Content Brief]
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