57152-56-4
57152-56-4
Chemical Structure
(R)-Primaquine
Synonym(s): (-)-Primaquine
- CAS No.: 57152-56-4
- Formula:C15H21N3O
- Molecular Weight:259.35
InChIKey: INDBQLZJXZLFIT-LLVKDONJSA-N
SMILES: COC(C=C1N[C@@H](CCCN)C)=CC2=C1N=CC=C2
Biological Activity: (R)-Primaquine ((−)-Primaquine) is the R-configured enantiomer of Primaquine (HY-12651A). (R)-Primaquine is an antimalarial agent. The Vmax and Km values of (R)-Primaquine metabolism by recombinant human CYP2D6 are 0.42 μmol/min/mg and 21.6 μM, respectively. (R)-Primaquine can be used in malaria-related research[1][2][3][4].
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(R)-Primaquine | (R)-Primaquine ((−)-Primaquine) is the R-configured enantiomer of Primaquine (HY-12651A). (R)-Primaquine is an antimalarial agent. The Vmax and Km values of (R)-Primaquine metabolism by recombinant human CYP2D6 are 0.42 μmol/min/mg and 21.6 μM, respectively. (R)-Primaquine can be used in malaria-related research. | |||||||||||||||||||||
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References
- [1]. Fasinu PS, et al. Enantioselective metabolism of primaquine by human CYP2D6. Malaria journal. 2014 Dec 17;13:507. [Content Brief]
- [2]. Chairat K, et al. Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs. The Journal of antimicrobial chemotherapy. 2018 Nov 01;73(11):3102-3113. [Content Brief]
- [3]. Nanayakkara NP, et al. Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers. Antimicrobial agents and chemotherapy. 2014 Aug;58(8):4737-44. [Content Brief]
- [4]. Saunders D, et al. Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta). Antimicrobial agents and chemotherapy. 2014 Dec;58(12):7283-91. [Content Brief]
Keywords
