57333-96-7
Chemical Structure
Tacalcitol
Synonym(s): 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3
- CAS No.: 57333-96-7
- Formula:C27H44O3
- Molecular Weight:416.64
IUPAC Name: (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5R)-5-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
InChIKey: BJYLYJCXYAMOFT-RSFVBTMBSA-N
SMILES: C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CC[C@H](C(C)C)O)C)CCC/2)[H])O)O
Biological Activity: Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases[1][2][3][4][5].
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Tacalcitol | 99.71% | Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases. | ||||||||||||||||||||
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Tacalcitol (Standard) | ≥98% | Tacalcitol (Standard) is the analytical standard of Tacalcitol. This product is intended for research and analytical applications. Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases. | ||||||||||||||||||||
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- [1]. Rostkowska-Nadolska B, et al. Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Adv Med Sci. 2010;55(1):86-92. [Content Brief]
- [2]. Kobayashi T, et al. 1 alpha,24R-dihydroxyvitamin D3 has an ability comparable to that of 1 alpha,25-dihydroxyvitamin D3 to induce keratinocyte differentiation. J Dermatol. 1990 Nov;17(11):707-9. [Content Brief]
- [3]. Matsumoto K, et al. K. Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes. J Dermatol. 1990 Feb;17(2):97-103. [Content Brief]
- [4]. Emanuelsson I, et al. Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells. Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):130-136. [Content Brief]
- [5]. Sato H, et al. Pharmacological profiles of high-concentration (20 microg/g) tacalcitol ointment: effects on cutaneous inflammation, epidermal proliferation, and differentiation in mice. J Dermatol. 2003 Jul;30(7):510-24. [Content Brief]
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