577696-37-8
Chemical Structure
Cardionogen 1
Synonym(s): CDNG1/vuc230
- CAS No.: 577696-37-8
- Formula:C13H14N4OS
- Molecular Weight:274.34
IUPAC Name: 6-Cyclohexyl-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
InChIKey: SWTUPSNBTSPBIH-UHFFFAOYSA-N
SMILES: C12=NN=C(C3=CC=CO3)N1N=C(C4CCCCC4)S2
Biological Activity: Cardionogen 1 (CDNG1/vuc230) is a Wnt signaling pathway inhibitor that slows down Myc-induced liver tumorigenesis. Cardionogen 1 treatment of zebrafish embryos before gastrulation inhibits cardiomyocyte formation, whereas treatment during or after gastrulation induces cardiomyocyte formation. Cardionogen 1 has potential in research into cancer and cardiovascular disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cardionogen 1 | 99.21% | Cardionogen 1 (CDNG1/vuc230) is a Wnt signaling pathway inhibitor that slows down Myc-induced liver tumorigenesis. Cardionogen 1 treatment of zebrafish embryos before gastrulation inhibits cardiomyocyte formation, whereas treatment during or after gastrulation induces cardiomyocyte formation. Cardionogen 1 has potential in research into cancer and cardiovascular disease. | ||||||||||||||||||||
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References
- [1]. Yan C, et al. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017 Apr 5;7:45796. [Content Brief]
- [2]. Plowright AT, et al. Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents. Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4056-75. [Content Brief]
