57930-92-4
Chemical Structure
20-Hydroxy-PGF2α
- CAS No.: 57930-92-4
- Formula:C20H34O6
- Molecular Weight:370.48
IUPAC Name: (Z)-7-((1R,2R,3R,5S)-2-((S,E)-3,8-dihydroxyoct-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid
InChIKey: XQXUYZDBZCLAQO-UNKHNRNISA-N
SMILES: OC(CCC/C=C\C[C@@H]([C@H](C1)O)[C@H]([C@@H]1O)/C=C/[C@@H](O)CCCCCO)=O
Biological Activity: 20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.
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20-Hydroxy-PGF2α | 20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway. | |||||||||||||||||||||
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Keywords
