58735-64-1
Chemical Structure
Roquefortine C
- CAS No.: 58735-64-1
- Formula:C22H23N5O2
- Molecular Weight:389.45
IUPAC Name: (5aS,10bR,11aS,E)-3-((1H-imidazol-5-yl)methylene)-10b-(2-methylbut-3-en-2-yl)-2,3,6,10b,11,11a-hexahydro-4H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(5aH)-dione
InChIKey: SPWSUFUPTSJWNG-JJUKSXGLSA-N
SMILES: O=C([C@](N1C/2=O)([H])C[C@]3(C(C)(C)C=C)[C@@]1([H])NC4=C3C=CC=C4)NC2=C\C5=CN=CN5
Biological Activity: Roquefortine C is a mycotoxin that can be isolated from Penicillium species. Roquefortine C is an agonist of P-gp and an inhibitor of P450 3A and P450 1A. Roquefortine C can inhibit Gram-positive bacteria and also has certain neurotoxicity. Additionally, Roquefortine C can exert antitumor activity[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Roquefortine C | 98.03% | Roquefortine C is a mycotoxin that can be isolated from Penicillium species. Roquefortine C is an agonist of P-gp and an inhibitor of P450 3A and P450 1A. Roquefortine C can inhibit Gram-positive bacteria and also has certain neurotoxicity. Additionally, Roquefortine C can exert antitumor activity. | ||||||||||||||||||||
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Roquefortine C-13C22 | Roquefortine C-13C22 is the 13C-labeled Roquefortine C (HY-N6748). Roquefortine C is a mycotoxin that can be isolated from Penicillium species. Roquefortine C is an agonist of P-gp and an inhibitor of P450 3A and P450 1A. Roquefortine C can inhibit Gram-positive bacteria and also has certain neurotoxicity. Additionally, Roquefortine C can exert antitumor activity. | |||||||||||||||||||||
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References
- [1]. Mady MS, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016 Jan 15;24(2):113-22. [Content Brief]
- [2]. Aninat C, et al. Oxidative metabolism by P450 and function coupling to efflux systems: modulation of mycotoxin toxicity. Food Addit Contam. 2005 Apr;22(4):361-8. [Content Brief]
- [3]. García-Rico RO, et al. Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti. Food Addit Contam. 2005 Apr;22(4):361-8. [Content Brief]
- [4]. Tiwary AK, et al. Using roquefortine C as a biomarker for penitrem A intoxication. J Vet Diagn Invest. 2009 Mar;21(2):237-9. [Content Brief]
- [5]. Deng XJ, et al. Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3'-UTR of SIRT1 and inhibiting its expression. Cell Signal. 2021 Aug;84:110016. [Content Brief]
