Roquefortine C
Based on 1 publication(s) in Google Scholar
Roquefortine C is a mycotoxin that can be isolated from Penicillium species. Roquefortine C is an agonist of P-gp and an inhibitor of P450 3A and P450 1A. Roquefortine C can inhibit Gram-positive bacteria and also has certain neurotoxicity. Additionally, Roquefortine C can exert antitumor activity.
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- Pureza: 98.03%
- No. CAS: 58735-64-1
- Fòrmula: C22H23N5O2
- Peso molecular:389.45
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Roquefortine C
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | IC50 |
29.6 μM
Compound: 2; Roq C
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Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 26692349] |
| MCF7 | IC50 |
21.7 μM
Compound: 2; Roq C
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Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 26692349] |
| MDA-MB-231 | IC50 |
23.5 μM
Compound: 2; Roq C
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Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 26692349] |
| MDA-MB-468 | IC50 |
28.6 μM
Compound: 2; Roq C
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Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 26692349] |
| SK-BR-3 | IC50 |
23.4 μM
Compound: 2; Roq C
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Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 26692349] |
In Vitro
Roquefortine C (72 h) exhibits certain antiproliferative activity in c-Met-dependent human breast cancer cell lines, with an IC50 range of 21.7-29.6 μM[1].
Roquefortine C (5 μM; 1 h) can inhibit the phosphorylation of wild-type c-Met, with inhibition rates of 39.7% (5 μM) and 59.7% (10 μM)[1].
Roquefortine C (15-30 μM; 24 h) can inhibit HGF-induced invasion of MDA-MB-231 breast cancer cells[1].
Roquefortine C (>10 μM) exhibits cytotoxic effects towards human neuroblastoma cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:c-Met-dependent human breast cancer cell lines
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Concentration:/
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Incubation Time:72 h
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Result:Inhibited the cell viability, with IC50 values of 21.7, 24.4, 29.6, 23.4, 23.5, 28.6 μM for MCF7, MCF7-dox, BT-474, SKBR-3, MDA-MB-231, MDA-MB-468, respectively.
Chemical Information
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No. CAS 58735-64-1
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Appearance Solid
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Peso molecular 389.45
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Fòrmula C22H23N5O2
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Color White to off-white
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SMILES
O=C([C@](N1C/2=O)([H])C[C@]3(C(C)(C)C=C)[C@@]1([H])NC4=C3C=CC=C4)NC2=C\C5=CN=CN5
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Structure Classification
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Initial Source
Penicillium roqueforti
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Signal
Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3'-UTR of SIRT1 and inhibiting its expression. [Abstract]2021 Aug:84:110016. PMID: 33894312
Solvente y solubilidad
In Vitro:
DMSO : 10 mg/mL (25.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (285 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Mady MS, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016 Jan 15;24(2):113-22. [Content Brief]
[2]. Aninat C, et al. Oxidative metabolism by P450 and function coupling to efflux systems: modulation of mycotoxin toxicity. Food Addit Contam. 2005 Apr;22(4):361-8. [Content Brief]
[3]. García-Rico RO, et al. Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti. Food Addit Contam. 2005 Apr;22(4):361-8. [Content Brief]
[4]. Tiwary AK, et al. Using roquefortine C as a biomarker for penitrem A intoxication. J Vet Diagn Invest. 2009 Mar;21(2):237-9. [Content Brief]
[5]. Deng XJ, et al. Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3'-UTR of SIRT1 and inhibiting its expression. Cell Signal. 2021 Aug;84:110016. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5677 mL | 12.8386 mL | 25.6772 mL | 64.1931 mL |
| 5 mM | 0.5135 mL | 2.5677 mL | 5.1354 mL | 12.8386 mL | |
| 10 mM | 0.2568 mL | 1.2839 mL | 2.5677 mL | 6.4193 mL | |
| 15 mM | 0.1712 mL | 0.8559 mL | 1.7118 mL | 4.2795 mL | |
| 20 mM | 0.1284 mL | 0.6419 mL | 1.2839 mL | 3.2097 mL | |
| 25 mM | 0.1027 mL | 0.5135 mL | 1.0271 mL | 2.5677 mL |
Roquefortine C Related Classifications
HY-N6748 Related Classifications
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