5890-18-6
Chemical Structure
Laurolitsine
Synonym(s): (+)-Norboldine
- CAS. Nr.: 5890-18-6
- Formula:C18H19NO4
- Molecular Weight:313.35
IUPAC Name: (S)-1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
InChIKey: KYVJVURXKAZJRK-LBPRGKRZSA-N
SMILES: OC1=C(OC)C2=C3C(CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C24)=C1
Biological Activity: Laurolitsine ((+)-Norboldine) is a natural alkaloid and an orally active AMPK activator. Laurolitsine increases the ADP/ATP ratio and promotes upstream LKB1 phosphorylation, accompanied by downstream ACC phosphorylation and inhibition. Laurolitsine reduces fasting blood glucose, improves glucose tolerance and insulin resistance, lowers blood lipid levels and body weight gain, and ameliorates renal injury associated with diabetic nephropathy. Laurolitsine can be used for research on obesity in type 2 diabetes[1][2][3].
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Laurolitsine | Laurolitsine ((+)-Norboldine) is a natural alkaloid and an orally active AMPK activator. Laurolitsine increases the ADP/ATP ratio and promotes upstream LKB1 phosphorylation, accompanied by downstream ACC phosphorylation and inhibition. Laurolitsine reduces fasting blood glucose, improves glucose tolerance and insulin resistance, lowers blood lipid levels and body weight gain, and ameliorates renal injury associated with diabetic nephropathy. Laurolitsine can be used for research on obesity in type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Yong Z, et al. Laurolitsine ameliorates type 2 diabetes by regulating the hepatic LKB1-AMPK pathway and gut microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov;106:154423.
- [2]. Zhang Y, et al. Laurolitsine ameliorates insulin resistance, ovarian dysfunction and gut microbiota dysbiosis in DHEA plus HFD-induced PCOS mice. Frontiers in endocrinology. 2025;16:1517934.
- [3]. Tan YF, et al. Study on the pharmacokinetics, tissue distribution and excretion of laurolitsine from Litsea glutinosa in Sprague-Dawley rats. Pharm Biol. 2021 Dec;59(1):884-892.
