6001-74-7
6001-74-7
Chemical Structure
Chlormethiazole hydrochloride
Synonym(s): Clomethiazole hydrochloride
- CAS No.: 6001-74-7
- Formula:C6H9Cl2NS
- Molecular Weight:198.11
IUPAC Name: 5-(2-chloroethyl)-4-methylthiazole hydrochloride
InChIKey: OFXYKSLKNMTBHK-UHFFFAOYSA-N
SMILES: CC1=C(CCCl)SC=N1.Cl
Biological Activity: Clomethiazole hydrochloride is a potent and orally active GABAA agonist[1]. Clomethiazole hydrochloride inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Clomethiazole hydrochloride is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Chlormethiazole hydrochloride | 99.94% | Clomethiazole hydrochloride is a potent and orally active GABAA agonist. Clomethiazole hydrochloride inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Clomethiazole hydrochloride is an anticonvulsant agent and has the potential for treating convulsive status epilepticus. | ||||||||||||||||||||
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References
- [1]. Hohmann N, et al. Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease. Gut. 2022 Apr;71(4):842-844. [Content Brief]
- [2]. Hewitt KE, et al. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. 1994 Dec;33(12):1589-95. [Content Brief]
Keywords
