608-71-9
Chemical Structure
Pentabromophenol
Synonym(s): PBP
- CAS No.: 608-71-9
- Formula:C6HBr5O
- Molecular Weight:488.59
IUPAC Name: 2,3,4,5,6-pentabromophenol
InChIKey: SVHOVVJFOWGYJO-UHFFFAOYSA-N
SMILES: C1(=C(C(=C(C(=C1Br)Br)O)Br)Br)Br
Biological Activity: Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pentabromophenol | 99.94% | Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs). | ||||||||||||||||||||
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References
- [1]. Chen CL, et al. Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis. Sci Rep. 2017;7:43206. Published 2017 Feb 23. [Content Brief]
- [2]. Barańska A, et al. Apoptosis-Inducing Potential of Selected Bromophenolic Flame Retardants 2,4,6-Tribromophenol and Pentabromophenol in Human Peripheral Blood Mononuclear Cells. Molecules. 2022 Aug 9;27(16):5056. [Content Brief]
