616-02-4
Chemical Structure
Citraconic anhydride
Synonym(s): Methylmaleic anhydride
- CAS No.: 616-02-4
- Formula:C5H4O3
- Molecular Weight:112.08
IUPAC Name: 3-methylfuran-2,5-dione
InChIKey: AYKYXWQEBUNJCN-UHFFFAOYSA-N
SMILES: O=C1OC(C(C)=C1)=O
Biological Activity: Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride (HY-Z0060) and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3+ into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Citraconic anhydride | 99.81% | Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride (HY-Z0060) and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3+ into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes. | ||||||||||||||||||||
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- [1]. Hermanson G T. Chapter 2-functional targets for bioconjugation[J]. Bioconjugate Techniques, 2013, 3: 127-228.
- [2]. Devrim Y G, et al. Functionalization of isotactic polypropylene with citraconic anhydride. Polymer Bulletin, 2007, 59(4): 447-456.
- [3]. Yankeelov JA Jr, et al. Methylmaleic anhydride as a reversible blocking agent during specific arginine modification. Biochem Biophys Res Commun. 1971 Mar 5;42(5):886-91. [Content Brief]
- [4]. Melodia D, et al. Traceless pH-Sensitive Antibody Conjugation Inspired by Citraconic Anhydride. Biomacromolecules. 2022 Dec 12;23(12):5322-5329. [Content Brief]
- [5]. Leong AS, et al. Citraconic anhydride: a new antigen retrieval solution. Pathology. 2010 Jan;42(1):77-81. [Content Brief]
Keywords
