6403-35-6
Chemical Structure
Leucylproline
Synonym(s): Leu-Pro
- No. CAS: 6403-35-6
- Formula:C11H20N2O3
- Molecular Weight:228.29
IUPAC Name: L-leucyl-L-proline
InChIKey: VTJUNIYRYIAIHF-IUCAKERBSA-N
SMILES: O=C([C@H]1N(CCC1)C([C@@H](N)CC(C)C)=O)O
Biological Activity:
Leucylproline (Leu‑Pro) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of leucylproline is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline can be used for the study of metabolism‑related diseases[1][2].
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Leucylproline | Leucylproline (Leu‑Pro) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of leucylproline is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline can be used for the study of metabolism‑related diseases. |
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References
- [1]. Marugg JD, et al. Medium-dependent regulation of proteinase gene expression in Lactococcus lactis: control of transcription initiation by specific dipeptides. Journal of bacteriology. 1995 Jun;177(11):2982-9.
- [2]. Cai X, et al. Multi-omics study unravels gut microbiota and metabolites alteration in patients with Wilson's disease. Scientific reports. 2024 Sep 09;14(1):21025.
