67655-94-1
67655-94-1
Chemical Structure
Amastatin
- CAS No.: 67655-94-1
- Formula:C21H38N4O8
- Molecular Weight:474.55
IUPAC Name: ((2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl)-L-valyl-L-valyl-L-aspartic acid
InChIKey: QFAADIRHLBXJJS-ZAZJUGBXSA-N
SMILES: O=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](CC(C)C)N)O)=O)C(C)C)=O)C(C)C)=O)C(O)=O)O
Biological Activity: Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC50 of 0.54 μg/mL for AP-A[1][2].
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Amastatin | Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC50 of 0.54 μg/mL for AP-A. | |||||||||||||||||||||
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References
- [1]. Aoyagi T, et al. Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. J Antibiot (Tokyo). 1978 Jun;31(6):636-8. [Content Brief]
- [2]. Wilkes SH, et al. The slow, tight binding of bestatin and amastatin to aminopeptidases. J Biol Chem. 1985 Oct 25;260(24):13154-62. [Content Brief]
