6790-64-3
Chemical Structure
Aplysinol
- CAS 番号: 6790-64-3
- Formula:C15H19BrO2
- Molecular Weight:311.22
IUPAC Name: ((3S,3aS,8bS)-7-bromo-3,6,8b-trimethyl-1,2,3,8b-tetrahydro-3aH-cyclopenta[b]benzofuran-3a-yl)methanol
InChIKey: QKBMCQNYERBGHD-LKTVYLICSA-N
SMILES: C(O)[C@]12[C@](C)(C=3C(O1)=CC(C)=C(Br)C3)CC[C@@H]2C
Biological Activity: Aplysinol is an orally effective TLR4 signaling pathway inhibitor. Aplysinol reduces the expression of CD14, MyD88, and NF-κB p65, and downregulates the expression and secretion of TNF-α protein as well as the secretion of IL-1β. Aplysinol restores the phagocytic activity of Kupffer cells and reduces plasma endotoxin levels. Aplysinol alleviates alcohol-induced liver histopathological changes and inhibits the elevation of liver injury biomarkers, and can be used for research related to alcoholic liver disease[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Aplysinol | Aplysinol is an orally effective TLR4 signaling pathway inhibitor. Aplysinol reduces the expression of CD14, MyD88, and NF-κB p65, and downregulates the expression and secretion of TNF-α protein as well as the secretion of IL-1β. Aplysinol restores the phagocytic activity of Kupffer cells and reduces plasma endotoxin levels. Aplysinol alleviates alcohol-induced liver histopathological changes and inhibits the elevation of liver injury biomarkers, and can be used for research related to alcoholic liver disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
