6859-01-4
6859-01-4
Chemical Structure
Isorhynchophylline
- CAS No.: 6859-01-4
- Formula:C22H28N2O4
- Molecular Weight:384.47
IUPAC Name: methyl (E)-2-((3S,6'R,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate
InChIKey: DAXYUDFNWXHGBE-VKCGGMIFSA-N
SMILES: O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](CC)C4)([H])N4CC3
Biological Activity: Isorhynchophylline is an alkaloid isolated from Crocus sativus with anticancer, antihypertensive, anti-inflammatory, and neuroprotective properties. Isorhynchophylline can be applied to cardiovascular and neurological disorders, and cancer studies[1][2][3][4][5][6][7][8][9][10][11][12][13].
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Isorhynchophylline | 99.82% | Isorhynchophylline is an alkaloid isolated from Crocus sativus with anticancer, antihypertensive, anti-inflammatory, and neuroprotective properties. Isorhynchophylline can be applied to cardiovascular and neurological disorders, and cancer studies. | ||||||||||||||||||||
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Isorhynchophylline (Standard) | ≥98% | Isorhynchophylline (Standard) is the analytical standard of Isorhynchophylline. This product is intended for research and analytical applications. Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia. | ||||||||||||||||||||
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References
- [1]. Wang K, et al. Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla. J Nat Prod. 2011 Jan 28;74(1):12-5. [Content Brief]
- [2]. Yuan D, et al. Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. J Nat Prod. 2008 Jul;71(7):1271-4. [Content Brief]
- [3]. Zhang F, et al. Effects of isorhynchophylline on angiotensin II-induced proliferation in rat vascular smooth muscle cells. J Pharm Pharmacol. 2008 Dec;60(12):1673-8. [Content Brief]
- [4]. Lee H, et al. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. Int J Mol Sci. 2017 May 19;18(5):1095. [Content Brief]
- [5]. Xian YF, et al. Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:163057. [Content Brief]
- [6]. Wu Y, et al. Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/β-catenin axis. Autoimmunity. 2023 Dec;56(1):2289868. [Content Brief]
- [7]. Jiang J, et al. Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes. J Orthop Surg Res. 2023 Mar 2;18(1):154. [Content Brief]
- [8]. Zhao H, et al. Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway. Neurochem Res. 2021 Aug;46(8):1981-1994. [Content Brief]
- [9]. Xian YF, et al. Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice. Neurochem Int. 2014 Oct;76:42-9. [Content Brief]
- [10]. Xian YF, et al. Antidepressant-Like Effect of Isorhynchophylline in Mice. Neurochem Res. 2017 Feb;42(2):678-685. [Content Brief]
- [11]. Li HQ, et al. Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in mice. Chin Med. 2018 Jun 14;13:29. [Content Brief]
- [12]. Qiu M, et al. Protective effects of isorhynchophylline against silicon-dioxide-induced lung injury in mice. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1125-1134. [Content Brief]
- [13]. Guo H, et al. Isorhynchophylline protects against pulmonary arterial hypertension and suppresses PASMCs proliferation. Biochem Biophys Res Commun. 2014 Jul 18;450(1):729-34. [Content Brief]
