6883-44-9
Chemical Structure
Decumbensine
Synonym(s): (+)-Decumbensine; (+)-Egenine
- CAS No.: 6883-44-9
- Formula:C20H19NO6
- Molecular Weight:369.37
InChIKey: YMHFBUOKLSWOQF-NSHGMRRFSA-N
SMILES: CN1[C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)[C@H](O4)O
Biological Activity: Decumbensine ((+)-Egenine) is a phthalideisoquinoline hemiacetal alkaloid present in Corydalis decumbens[1][2][3]. Decumbensine significantly inhibits spontaneous calcium oscillations in primary cultured neocortical neurons, reducing oscillation frequency and amplitude[2]. Decumbensine can be used in studies related to central nervous system diseases, epilepsy and pain[1][2].
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Decumbensine | Decumbensine ((+)-Egenine) is a phthalideisoquinoline hemiacetal alkaloid present in Corydalis decumbens. Decumbensine significantly inhibits spontaneous calcium oscillations in primary cultured neocortical neurons, reducing oscillation frequency and amplitude. Decumbensine can be used in studies related to central nervous system diseases, epilepsy and pain. | |||||||||||||||||||||
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- [1]. Zhang JS,et al. Decumbensine and epi-α-Decumbensine: Two New Alkaloids Isolated from Corydalis decumbens. J Nat Prod. 1988 Nov-Dec;51(6):1241-1242.
- [2]. Zhang CL,et al. Phthalideisoquinoline Hemiacetal Alkaloids from Corydalis decumbens That Inhibit Spontaneous Calcium Oscillations, Including Alkyl Derivatives of (+)-Egenine That Are Strikingly Levorotatory. J Nat Prod. 2019 Oct 25;82(10):2713-2720. [Content Brief]
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[3]. Chang J,et al. Two novel isoquinoline alkaloids from the seedling of Corydalis decumbens. Tetrahedron Lett. 2015 Jan 1;56(1):225-228. doi: 10.1016/j.tetlet.2014.11.066.
Keywords
