706772-75-0
706772-75-0
Chemical Structure
NADs-IN-2
- CAS No.: 706772-75-0
- Formula:C19H14Cl2N4O5S
- Molecular Weight:481.31
InChIKey: BFCSQVMVMNEDEY-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(S(=O)(NC2=CC=C(C(Cl)=C2)Cl)=O)C=C1)NC3=CC=C([N+]([O-])=O)C=C3
Biological Activity: NADs-IN-2 is a NADSYN1 inhibitor. NADs-IN-2 also binds to the NaAD subsite within the active site of bacterial NADs, thereby inhibiting enzymatic function. NADs-IN-2 can be used in research related to anthrax and cancer[1][2].
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NADs-IN-2 | NADs-IN-2 is a NADSYN1 inhibitor. NADs-IN-2 also binds to the NaAD subsite within the active site of bacterial NADs, thereby inhibiting enzymatic function. NADs-IN-2 can be used in research related to anthrax and cancer. | |||||||||||||||||||||
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References
- [1]. Moro WB, et al. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & medicinal chemistry letters. 2009 Apr 01;19(7):2001-5.
- [2]. MISCHEL PS. Targeting NAD biosynthesis in the treatment of cancer: WO 2020/186240 A1. The Regents of the University of California; Ludwig Institute for Cancer Research; 2020 Sep 17.
