NADs-IN-2
NADs-IN-2 is a NADSYN1 inhibitor. NADs-IN-2 also binds to the NaAD subsite within the active site of bacterial NADs, thereby inhibiting enzymatic function. NADs-IN-2 can be used in research related to anthrax and cancer.
For research use only. We do not sell to patients.
- CAS No.: 706772-75-0
- Formula: C19H14Cl2N4O5S
- Molecular Weight:481.31
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
|
NADSYN1 |
In Vitro
NADs-IN-2 (5824) (0.6-600 μM; 10 min) potently inhibits purified Bacillus anthracis NAD synthetase, with an IC50 value of 10 μM[1].
NADs-IN-2 (1.88-240 μM; 5 h) completely inhibits the vegetative growth of *Bacillus anthracis* Sterne strain, with an MIC100 of 1.9 μM[1].
NADs-IN-2 (NADSYNli) (72 h) selectively kills cancer cells with amplified PH pathway, while exerts no significant effects on normal cells and cancer cells dependent on the salvage pathway[2].
NADs-IN-2 (2 μM; 72 h) fails to induce drug sensitivity in non-cancer cells (IMR90, RPE-1) with NAPRT- or NAMPT-overexpression[2].
NADs-IN-2 (1-3 μM; 30 min) inhibits the activity of purified human NADSYN1 enzyme in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:5-6 week-old female athymic nu/nu mice (nude mice)[1]
-
Dosage:10 mg/kg; 30mg/kg
-
Administration:i.p.; once daily; for two weeks
-
Result:Reduced the volume and intratumoral NAD+ levels of Preiss Handler pathway-dependent OV4PH-amp tumors in nude mice.
Had no significant effect on salvage pathway-dependent H460Sal-dep tumors.
Chemical Information
-
CAS No. 706772-75-0
-
Molecular Weight 481.31
-
Formula C19H14Cl2N4O5S
-
SMILES
O=C(NC1=CC=C(S(=O)(NC2=CC=C(C(Cl)=C2)Cl)=O)C=C1)NC3=CC=C([N+]([O-])=O)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NADs-IN-2 Related Classifications
HY-189475 Related Classifications
Powered by Bioz