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Cat. No.: HY-189475

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NADs-IN-2

Name: NADs-IN-2
Brand: MedChemExpress
SKU: HY-189475
Price: 170.00 USD
Availability: PreOrder

NADs-IN-2 is a NADSYN1 inhibitor. NADs-IN-2 also binds to the NaAD subsite within the active site of bacterial NADs, thereby inhibiting enzymatic function. NADs-IN-2 can be used in research related to anthrax and cancer.

For research use only. We do not sell to patients.

CAS No.: 706772-75-0
Formula: C₁₉H₁₄Cl₂N₄O₅S
Molecular Weight:481.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NADs-IN-2 Chemical Structure

CAS No.: 706772-75-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target

^[1]^[2]

NADSYN1

In Vitro

NADs-IN-2 (5824) (0.6-600 μM; 10 min) potently inhibits purified Bacillus anthracis NAD synthetase, with an IC₅₀ value of 10 μM^[1].
NADs-IN-2 (1.88-240 μM; 5 h) completely inhibits the vegetative growth of *Bacillus anthracis* Sterne strain, with an MIC₁₀₀ of 1.9 μM^[1].
NADs-IN-2 (NADSYNli) (72 h) selectively kills cancer cells with amplified PH pathway, while exerts no significant effects on normal cells and cancer cells dependent on the salvage pathway^[2].
NADs-IN-2 (2 μM; 72 h) fails to induce drug sensitivity in non-cancer cells (IMR90, RPE-1) with NAPRT- or NAMPT-overexpression^[2].
NADs-IN-2 (1-3 μM; 30 min) inhibits the activity of purified human NADSYN1 enzyme in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

NADs-IN-2 (NADSYNli) (10-30 mg/kg; i.p.; once daily; for two weeks) reduces the volume and intratumoral NAD⁺ level of Preiss Handler pathway-dependent OV4^PH-amp tumors in nude mice, but exerts no significant effect on salvage pathway-dependent H460^Sal-dep tumors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5-6 week-old female athymic nu/nu mice (nude mice)^[1]
Dosage:

10 mg/kg; 30mg/kg
Administration:

i.p.; once daily; for two weeks
Result:

Reduced the volume and intratumoral NAD⁺ levels of Preiss Handler pathway-dependent OV4^PH-amp tumors in nude mice.
Had no significant effect on salvage pathway-dependent H460^Sal-dep tumors.

Chemical Information

CAS No. 706772-75-0
Molecular Weight 481.31
Formula C₁₉H₁₄Cl₂N₄O₅S
SMILES

O=C(NC1=CC=C(S(=O)(NC2=CC=C(C(Cl)=C2)Cl)=O)C=C1)NC3=CC=C([N+]([O-])=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Moro WB, et al. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & medicinal chemistry letters. 2009 Apr 01;19(7):2001-5.

[2]. MISCHEL PS. Targeting NAD biosynthesis in the treatment of cancer: WO 2020/186240 A1. The Regents of the University of California; Ludwig Institute for Cancer Research; 2020 Sep 17.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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