714272-27-2
714272-27-2
Chemical Structure
Plinabulin
Synonym(s): NPI-2358
- CAS No.: 714272-27-2
- Formula:C19H20N4O2
- Molecular Weight:336.39
IUPAC Name: (Z)-3-((Z)-benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione
InChIKey: UNRCMCRRFYFGFX-TYPNBTCFSA-N
SMILES: O=C(N/C1=C\C2=C(NC=N2)C(C)(C)C)/C(NC1=O)=C/C3=CC=CC=C3
Biological Activity: Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells[1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Plinabulin | 98.0% | Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. | ||||||||||||||||||||
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Plinabulin-d1 | Plinabulin-d1 is an active compound. | |||||||||||||||||||||
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References
- [1]. Nicholson B et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs. 2006 Jan;17(1):25-31. [Content Brief]
- [2]. Monica M. Mita et al. Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas Clin Cancer Res. 2010 Dec 1;16(23):5892-9. [Content Brief]
