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Cat. No.: HY-123707

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KPU-300

KPU-300 (compound 6b) is a tubulin inhibitor. KPU-300 has potent cytotoxicity with an IC₅₀ value of 7.0 nM against HT-29 cells.

For research use only. We do not sell to patients.

CAS No.: 1620692-60-5
Formula: C₂₄H₁₇N₃O₃
Molecular Weight:395.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KPU-300 Chemical Structure

CAS No.: 1620692-60-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KPU-300 (compound 6b) is a tubulin inhibitor. KPU-300 has potent cytotoxicity with an IC₅₀ value of 7.0 nM against HT-29 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14.2 nM Compound: 6b, KPU-300	Cytotoxicity against human A549 cells after 48 hrs by WST8 assay Cytotoxicity against human A549 cells after 48 hrs by WST8 assay	[PMID: 25313318]
BXPC-3	IC₅₀	6.27 nM Compound: 2	Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine B assay	[PMID: 29571653]
BXPC-3	IC₅₀	6.3 nM Compound: KPU-300	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32278711]
HeLa	IC₅₀	5.4 nM Compound: 6b, KPU-300	Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay	[PMID: 25313318]
HT-29	IC₅₀	7 nM Compound: 6b, KPU-300	Cytotoxicity against human HT-29 cells after 48 hrs by XTT/PMS assay Cytotoxicity against human HT-29 cells after 48 hrs by XTT/PMS assay	[PMID: 25313318]
HT-29	IC₅₀	7 nM Compound: KPU-300	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32278711]

Chemical Information

CAS No. 1620692-60-5
Molecular Weight 395.41
Formula C₂₄H₁₇N₃O₃
SMILES

O=C(/C(NC/1=O)=C/C2=CC=CC(C(C3=CC=CC=C3)=O)=C2)NC1=C/C4=NC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yoshiki Hayashi, et al. Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure. ACS Med Chem Lett. 2014 Jul 23;5(10):1094-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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