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Art. -Nr.: HY-116518

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Piperafizine A

Piperafizine A (compound 4d’) is a N-monoalkylated plinabulin derivative. Anti-cancer reagent.

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CAS. Nr.: 130603-59-7
Formel: C₁₉H₁₆N₂O₂
Molecular Weight:304.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Piperafizine A Chemical Structure

CAS. Nr.: 130603-59-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Piperafizine A (compound 4d’) is a N-monoalkylated plinabulin derivative. Anti-cancer reagent^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.8 μM Compound: Piperafizine A	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]
DU-145	IC₅₀	9.4 μM Compound: Piperafizine A	Cytotoxicity against human DU-145 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human DU-145 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]
HeLa	IC₅₀	4.9 μM Compound: Piperafizine A	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]
HT-29	IC₅₀	6.5 μM Compound: Piperafizine A	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]
K562	IC₅₀	2.9 μM Compound: Piperafizine A	Cytotoxicity against human K562 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]
MCF7	IC₅₀	5.1 μM Compound: Piperafizine A	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]
U-937	IC₅₀	1.4 μM Compound: Piperafizine A	Cytotoxicity against human U-937 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human U-937 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 27318124]

Chemical Information

CAS. Nr. 130603-59-7
Molecular Weight 304.34
Formel C₁₉H₁₆N₂O₂
SMILES

O=C(N(/C1=C\C2=CC=CC=C2)C)/C(NC1=O)=C/C3=CC=CC=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Asha Ganesher, et al. One pot synthesis of N-monoalkylated plinabulin derivatives via multicomponent protocol and their application as anticancer agents. J Mol Struct. 2020;1229:129830.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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