71865-60-6
71865-60-6
Chemical Structure
TOFyl-CoA
- CAS No.: 71865-60-6
- Formula:C40H66N7O19P3S
- Molecular Weight:1073.97
InChIKey: NXAHLFOPZQJPNH-LFZQUHGESA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(C4=CC=C(OCCCCCCCCCCCCCC)O4)=O)=O)=O)O)C)=O)=O)O3
Biological Activity: TOFyl-CoA is an intracellular metabolite of TOFA (HY-101068) and a more potent ACC inhibitor. TOFyl-CoA exerts allosteric inhibition on ACC1 and ACC2 by competing with acetyl-CoA in the carboxyltransferase reaction[1][2].
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TOFyl-CoA | TOFyl-CoA is an intracellular metabolite of TOFA (HY-101068) and a more potent ACC inhibitor. TOFyl-CoA exerts allosteric inhibition on ACC1 and ACC2 by competing with acetyl-CoA in the carboxyltransferase reaction. | |||||||||||||||||||||
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References
- [1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]
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[2]. Huang H, et al. Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose. PPAR Res. 2013;2013:865604. https://doi.org/10.1155/2013/865604
