71997-34-7
Chemical Structure
Ara-ATP trisodium
- No. CAS: 71997-34-7
- Formula:C10H13N5Na3O13P3
- Molecular Weight:573.13
IUPAC Name: ((2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate, trisodium salt
InChIKey: VGTKNLQPBHGQOU-CBHZIYPBSA-K
SMILES: O[C@H]1[C@H](O)[C@@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C23
Biological Activity: Ara-ATP trisodium is an ATP-competitive poly (A) polymerase (poly (A) polymerase) inhibitor with a Ki value of 4 μM for the chromatin-bound form and a Ki value of 60 μM for the nucleoplasmic (free) form. Ara-ATP trisodium blocks pre-mRNA 3' end processing by inhibiting endonucleolytic cleavage, poly (A) addition, and the formation of cleavage and polyadenylation-specific RNA-protein complexes. Ara-ATP trisodium selectively inhibits initial polyadenylation rather than poly (A) elongation. Ara-ATP trisodium is used in the study of viral infections[1][2].
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Ara-ATP trisodium | Ara-ATP trisodium is an ATP-competitive poly (A) polymerase (poly (A) polymerase) inhibitor with a Ki value of 4 μM for the chromatin-bound form and a Ki value of 60 μM for the nucleoplasmic (free) form. Ara-ATP trisodium blocks pre-mRNA 3' end processing by inhibiting endonucleolytic cleavage, poly (A) addition, and the formation of cleavage and polyadenylation-specific RNA-protein complexes. Ara-ATP trisodium selectively inhibits initial polyadenylation rather than poly (A) elongation. Ara-ATP trisodium is used in the study of viral infections. | |||||||||||||||||||||
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References
- [1]. Ghoshal K, et al. Ara-ATP impairs 3'-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation. Nucleic acids research. 1991 Nov 11;19(21):5871-5. [Content Brief]
- [2]. Rose KM, et al. Selective inhibition of RNA polyadenylation by Ara-ATP in vitro: a possible mechanism for antiviral action of Ara-A. Biochem Biophys Res Commun. 1978 Apr 28;81(4):1418-24.
