752191-77-8
752191-77-8
Chemical Structure
FLT3-IN-18
- CAS No.: 752191-77-8
- Formula:C26H36N8O
- Molecular Weight:476.62
IUPAC Name: N2-((1r,4r)-4-aminocyclohexyl)-9-cyclopentyl-N6-(4-morpholinophenyl)-9H-purine-2,6-diamine
InChIKey: RBJJYZNTQRAUAB-KESTWPANSA-N
SMILES: N[C@H](CC1)CC[C@@H]1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3)=C5N=CN(C6CCCC6)C5=N2
Biological Activity: FLT3-IN-18 is a potent and selective FLT3 inhibitor with an IC50 value of 0.003 μM. FLT3-IN-18 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-18 inhibits FLT3 and STAT5 phosphorylation. FLT3-IN-18 has the potential for the research of acute myeloid leukemia (AML)[1].
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FLT3-IN-18 | FLT3-IN-18 is a potent and selective FLT3 inhibitor with an IC50 value of 0.003 μM. FLT3-IN-18 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-18 inhibits FLT3 and STAT5 phosphorylation. FLT3-IN-18 has the potential for the research of acute myeloid leukemia (AML). | |||||||||||||||||||||
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