75431-54-8
Chemical Structure
Adenosine 3',5'-diphosphate disodium
- CAS No.: 75431-54-8
- Formula:C10H13N5Na2O10P2
- Molecular Weight:471.16
IUPAC Name: sodium (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxyoxidophosphoryl)oxy)methyl)tetrahydrofuran-3-yl hydrogen phosphate
InChIKey: PQHHAKIJTDLQLS-IDIVVRGQSA-L
SMILES: O[C@H]([C@@H]1O[P](O)(O[Na])=O)[C@](O[C@@H]1CO[P](O)(O[Na])=O)([H])N2C3=NC=NC(N)=C3N=C2
Biological Activity: Adenosine 3',5'-diphosphate disodium is an endogenous purine nucleotide. Adenosine 3',5'-diphosphate disodium acts as an inhibitor of bovine adrenal estrogen sulfotransferase (EST) with a Ki value of 7.0 μM. It also serves as an indispensable specific cofactor for the pregnenolone-binding protein (PBP) steroid-binding complex, with an EC50 value of 1.5 μM in guinea pigs[1][2].
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Adenosine 3',5'-diphosphate disodium | 99% | Adenosine 3',5'-diphosphate disodium is an endogenous purine nucleotide. Adenosine 3',5'-diphosphate disodium acts as an inhibitor of bovine adrenal estrogen sulfotransferase (EST) with a Ki value of 7.0 μM. It also serves as an indispensable specific cofactor for the pregnenolone-binding protein (PBP) steroid-binding complex, with an EC50 value of 1.5 μM in guinea pigs. | ||||||||||||||||||||
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- [1]. Horwitz JP, et al. IV. Synthesis and assay of analogs of adenosine 3',5'-diphosphate as inhibitors of bovine adrenal estrogen sulfotranferase. Biochim Biophys Acta. 1978;525(2):364-372. [Content Brief]
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[2]. Lee YC, et al. Purification and identification of the heat-stable factor required for pregnenolone-binding protein activity. Evidence that the factor is adenosine 3 ‘, 5 ‘-diphosphate. Journal of Biological Chemistry. 1992 Jun 5;267(16):10982-7.
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