75684-07-0
Chemical Structure
Bremazocine
- CAS No.: 75684-07-0
- Formula:C20H29NO2
- Molecular Weight:315.45
IUPAC Name: (2R,6S)-6-ethyl-3-((1-hydroxycyclopropyl)methyl)-11,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocin-8-ol
InChIKey: ZDXGFIXMPOUDFF-XLIONFOSSA-N
SMILES: CC[C@]1(CCN2CC3(CC3)O)C4=CC(O)=CC=C4C[C@]2([H])C(C)1C
Biological Activity: Bremazocine is a potent opioid kappa receptor agonist with analgesic activity. Bremazocine induces peripheral analgesia by releasing endogenous norepinephrine. The analgesic effect of bremazocine is associated with interaction with adenosine receptors. Bremazocine produces a dose-dependent peripheral analgesia after topical application. The effect of bremazocine is affected by nonselective α(2) adrenaline receptor antagonists, suggesting that it acts through a norepinephrine pathway[1].
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Bremazocine | Bremazocine is a potent opioid kappa receptor agonist with analgesic activity. Bremazocine induces peripheral analgesia by releasing endogenous norepinephrine. The analgesic effect of bremazocine is associated with interaction with adenosine receptors. Bremazocine produces a dose-dependent peripheral analgesia after topical application. The effect of bremazocine is affected by nonselective α(2) adrenaline receptor antagonists, suggesting that it acts through a norepinephrine pathway. | |||||||||||||||||||||
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Keywords
