76-84-6
76-84-6
Chemical Structure
Triphenylmethanol
Synonym(s): Trt-OH
- CAS No.: 76-84-6
- Formula:C19H16O
- Molecular Weight:260.34
IUPAC Name: triphenylmethanol
InChIKey: LZTRCELOJRDYMQ-UHFFFAOYSA-N
SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Biological Activity: Triphenylmethanol (Trt-OH) is an agonist of PXR and CAR1. Triphenylmethanol shows no significant ligand effect on CAR3-dependent transactivation. Triphenylmethanol also serves as an intermediate for the synthesis of AMPKα1 activators. The Triphenylmethanol-Doxorubicin (HY-15142A) conjugate exerts anticancer effects against leukemia, ovarian adenocarcinoma, colorectal cancer, and breast cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Triphenylmethanol | 99.84% | Triphenylmethanol (Trt-OH) is an agonist of PXR and CAR1. Triphenylmethanol shows no significant ligand effect on CAR3-dependent transactivation. Triphenylmethanol also serves as an intermediate for the synthesis of AMPKα1 activators. The Triphenylmethanol-Doxorubicin (HY-15142A) conjugate exerts anticancer effects against leukemia, ovarian adenocarcinoma, colorectal cancer, and breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Triphenylmethanol (Standard) | ≥98% | Triphenylmethanol (Standard) (Trt-OH (Standard)) is the analytical standard of Triphenylmethanol (HY-W011788). This product is intended for research and analytical applications. Triphenylmethanol (Trt-OH) is an agonist of PXR and CAR1. Triphenylmethanol shows no significant ligand effect on CAR3-dependent transactivation. Triphenylmethanol also serves as an intermediate for the synthesis of AMPKα1 activators. The Triphenylmethanol-Doxorubicin (HY-15142A) conjugate exerts anticancer effects against leukemia, ovarian adenocarcinoma, colorectal cancer, and breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Boadi WY, et al. Targeting AMPKa1 Gene in PC3 Cells by Triphenylmethanol Derivatives. Natural Science. 2024;16(7):111-20.
- [2]. Alnakhli J, et al. Triphenylmethanol Conjugates of Triptorelin as Cell-Penetrating Anti-Cancer Prodrugs. Journal of Biosciences and Medicines. 2023;11:208-18.
- [3]. Dring AM, et al. Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. Chemico-biological interactions. 2010 Dec 05;188(3):512-25.
- [4]. Beni Y, et al. Design and antiproliferative evaluation of cell-penetrating TPM-Dox conjugates as prodrugs. Cancer Research. 2014 Oct 1;74(19_Supplement):2512-.
