76472-88-3
76472-88-3
Chemical Structure
Morachalcone A
- CAS No.: 76472-88-3
- Formula:C20H20O5
- Molecular Weight:340.37
IUPAC Name: (E)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
InChIKey: NXBYIJSAISXPKJ-WEVVVXLNSA-N
SMILES: OC(C=C(O)C=C1)=C1/C=C/C(C2=C(C(C/C=C(C)/C)=C(O)C=C2)O)=O
Biological Activity: Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].
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Morachalcone A | Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production. | |||||||||||||||||||||
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References
- [1]. Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002.
- [2]. Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009.
- [3]. Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9. [Content Brief]
Keywords
