77181-69-2
77181-69-2
Chemical Structure
Sorivudine
Synonym(s): BV-araU
- CAS No.: 77181-69-2
- Formula:C11H13BrN2O6
- Molecular Weight:349.13
IUPAC Name: 5-((E)-2-bromovinyl)-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: GCQYYIHYQMVWLT-HQNLTJAPSA-N
SMILES: O=C1NC(C(/C=C/Br)=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O)=O
Biological Activity: Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sorivudine | 99.69% | Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis. | ||||||||||||||||||||
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L-5-Methyluridine | L-5-Methyluridine is the L-configuration of 5-Methyluridine (HY-W009444). 5-Methyluridine is an endogenous methylated nucleoside. | |||||||||||||||||||||
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1-(β-D-Xylofuranosyl)-5-methyluracil | 1-(β-D-Xylofuranosyl)-5-methyluracil is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. | |||||||||||||||||||||
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Alpha-5-Methyluridine | Alpha-5-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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5-Methyluridine | ≥99.9% | 5-Methyluridine (m5U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing. | ||||||||||||||||||||
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5-Methyluridine-1′-13C | 5-Methyluridine-1′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-2′-13C | 5-Methyluridine-2′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-3′-13C | 5-Methyluridine-3′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-5′-13C | 5-Methyluridine-5′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Vinyl-uridine | 5-Vinyl-uridine is a fluorescent probe that can be used for intracellular RNA imaging, cell division stage imaging, and in vivo tumor imaging in mice. The detection mechanism of 5-Vinyl-uridine relies on metabolic incorporation into cellular RNA during RNA synthesis; after incorporation, it undergoes a bioorthogonal Diels-Alder reaction with Biotin (HY-B0511)-tetrazine. When paired with Streptavidin (HY-P3152)-Alexa Fluor 488, 5-Vinyl-uridine has an Ex/Em = 488/500-550 nm; when using Biotin-tetrazine, the emission peak is at approximately 510 nm, with the excitation/emission filter settings of 450-490/500-550 nm. 5-Vinyl-uridine can be used in tumor-related research. | |||||||||||||||||||||
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5-Methyluridine-13C5 | 5-Methyluridine-13C5 is 13C labeled 5-Methyluridine. | |||||||||||||||||||||
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