77690-92-7
Chemical Structure
6'''-Feruloylspinosin
- CAS No.: 77690-92-7
- Formula:C38H40O18
- Molecular Weight:784.71
IUPAC Name: ((2R,3S,4S,5R,6S)-6-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-2-(5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromen-6-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
InChIKey: WZAXZHIVHPRTIU-IHIXZLSHSA-N
SMILES: O[C@@H]1[C@H]([C@H](C(C(O)=C(C2=O)C(OC(C3=CC=C(O)C=C3)=C2)=C4)=C4OC)O[C@H](CO)[C@H]1O)O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5COC(/C=C/C6=CC(OC)=C(O)C=C6)=O
Biological Activity: 6'''-Feruloylspinosin is an orally active RORα activator that crosses the blood-brain barrier, with a Kd of 0.308 μM, and is found in natural sources. 6'''-Feruloylspinosin modulates AMPK and mTOR phosphorylation. 6'''-Feruloylspinosin promotes autophagy through the AMPK/mTOR signaling pathway, inhibits GSK3β phosphorylation at Tyr216, and activates the PGC-1α/Nrf2/HO-1 pathway. 6'''-Feruloylspinosin regulates neurotransmitter levels, enhances mRNA expression of GABAA α1, α5, and GABAB R1 receptor subunits, increases brain 5-HT and GABA, restores melatonin levels, and ameliorates anxiety-like behaviors. 6'''-Feruloylspinosin regulates oxidative stress homeostasis, inhibits mitochondrial dysfunction, decreases MDA while increasing GSH. 6'''-Feruloylspinosin can be used for research on Alzheimer's disease, acute myocardial infarction, heart failure with insomnia, and insomnia[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6'''-Feruloylspinosin | 99.65% | 6'''-Feruloylspinosin is an orally active RORα activator that crosses the blood-brain barrier, with a Kd of 0.308 μM, and is found in natural sources. 6'''-Feruloylspinosin modulates AMPK and mTOR phosphorylation. 6'''-Feruloylspinosin promotes autophagy through the AMPK/mTOR signaling pathway, inhibits GSK3β phosphorylation at Tyr216, and activates the PGC-1α/Nrf2/HO-1 pathway. 6'''-Feruloylspinosin regulates neurotransmitter levels, enhances mRNA expression of GABAA α1, α5, and GABAB R1 receptor subunits, increases brain 5-HT and GABA, restores melatonin levels, and ameliorates anxiety-like behaviors. 6'''-Feruloylspinosin regulates oxidative stress homeostasis, inhibits mitochondrial dysfunction, decreases MDA while increasing GSH. 6'''-Feruloylspinosin can be used for research on Alzheimer's disease, acute myocardial infarction, heart failure with insomnia, and insomnia. | ||||||||||||||||||||
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References
- [1]. Liu J, et al. 6‴-Feruloylspinosin alleviates Aβ-induced toxicity by modulating relevant neurotransmitter and the AMPK/mTOR signaling pathway. Free radical biology & medicine. 2025 Feb 01;227:434-445. [Content Brief]
- [2]. Gu M, et al. Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats. Molecular medicine reports. 2019 Nov;20(5):4253-4261. [Content Brief]
- [3]. Yan Y, et al. 6‴-Feruloylspinosin ameliorates pressure overload-induced heart failure with comorbid insomnia through the activation of RORα. British journal of pharmacology. 2026 Apr;183(7):1557-1577.
- [4]. Qiao L, et al. A HPLC-MS/MS method for determination of 6'''-feruloylspinosin in rat plasma and tissues: Pharmacokinetics and tissue distribution study. Journal of pharmaceutical and biomedical analysis. 2016 Mar 20;121:77-83. [Content Brief]
