790663-33-1
790663-33-1
Chemical Structure
PBD-150
- CAS No.: 790663-33-1
- Formula:C15H20N4O2S
- Molecular Weight:320.41
IUPAC Name: 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea
InChIKey: FZQXMGLQANXZRP-UHFFFAOYSA-N
SMILES: S=C(NCCCN1C=CN=C1)NC2=CC=C(OC)C(OC)=C2
Biological Activity: PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PBD-150 | 99.53% | PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.73
HY-116999IR415 -
Similarity Score 0.67
HY-151354Antibacterial agent 121 -
Similarity Score 0.60
HY-121611HI-236 -
Similarity Score 0.60
HY-101282Glutaminyl Cyclase Inhibitor 3 -
Similarity Score 0.58
HY-15390Thiambutosine -
Similarity Score 0.58
HY-106067ARDazoxiben hydrochloride (Standard) -
Similarity Score 0.57
![1,1′-[(2,5-Dimethoxy-1,4-phenylene)bis(methylene)]bis[1H-imidazole] Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586958.gif)
HY-W5869581,1′-[(2,5-Dimethoxy-1,4-phenylene)bis(methylene)]bis[1H-imidazole] -
Similarity Score 0.57
HY-106067Dazoxiben -
Similarity Score 0.57
HY-111798AHeme Oxygenase-1-IN-1 hydrochloride -
Explore the MedChemAI to find more analogs
![1,1′-[(2,5-Dimethoxy-1,4-phenylene)bis(methylene)]bis[1H-imidazole] Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586958.gif)
References
- [1]. Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77. [Content Brief]
- [2]. DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92. [Content Brief]
