790663-33-1
790663-33-1
Chemical Structure
PBD-150
- CAS No.: 790663-33-1
- Formula:C15H20N4O2S
- Molecular Weight:320.41
IUPAC Name: 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea
InChIKey: FZQXMGLQANXZRP-UHFFFAOYSA-N
SMILES: S=C(NCCCN1C=CN=C1)NC2=CC=C(OC)C(OC)=C2
Biological Activity: PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PBD-150 | 99.53% | PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM. | ||||||||||||||||||||
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References
- [1]. Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77. [Content Brief]
- [2]. DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92. [Content Brief]
Keywords
