79548-73-5
Chemical Structure
Pirlimycin
- CAS No.: 79548-73-5
- Formula:C17H31ClN2O5S
- Molecular Weight:410.96
IUPAC Name: (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-4-ethylpiperidine-2-carboxamide
InChIKey: HBJOXQRURQPDEX-MHXMMLMNSA-N
SMILES: O=C([C@@H]1C[C@@H](CCN1)CC)N[C@]([C@@]2([H])O[C@@H]([C@H](O)[C@@H](O)[C@H]2O)SC)([H])[C@@H](Cl)C
Biological Activity: Pirlimycin is an orally active lincosamide Antibiotic, Clindamycin (HY-B1455) analog, and antimalarial agent. Pirlimycin inhibits Plasmodium growth. Pirlimycin exhibits antibacterial activity against various aerobic bacteria, particularly Staphylococcus and Streptococcus species. Pirlimycin can be used for research on bovine mastitis[1][2][3][4][5][6][7].
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Pirlimycin | Pirlimycin is an orally active lincosamide Antibiotic, Clindamycin (HY-B1455) analog, and antimalarial agent. Pirlimycin inhibits Plasmodium growth. Pirlimycin exhibits antibacterial activity against various aerobic bacteria, particularly Staphylococcus and Streptococcus species. Pirlimycin can be used for research on bovine mastitis. | |||||||||||||||||||||
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References
- [1]. Gogoi-Tiwari J, et al. Mammary Gland Pathology Subsequent to Acute Infection with Strong versus Weak Biofilm Forming Staphylococcus aureus Bovine Mastitis Isolates: A Pilot Study Using Non-Invasive Mouse Mastitis Model. PloS one. 2017;12(1):e0170668.
- [2]. Hamed MI, et al. Mastitogenic Bacteria Isolated from Clinical Mastitis Cases Associated with Teat Lesions and their Antimicrobial Sensitivity. Journal of Advanced Veterinary Research. 2016 Apr 1;6(2):65-71.
- [3]. Tomazi T, et al. Molecular characterization and antimicrobial susceptibility pattern of Streptococcus agalactiae isolated from clinical mastitis in dairy cattle. PloS one. 2018;13(6):e0199561.
- [4]. Birkenmeyer RD, et al. Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent. Journal of medicinal chemistry. 1984 Feb;27(2):216-23. [Content Brief]
- [5]. Kopia GA, et al. Antiarrhythmic and cardiovascular actions of the new antibiotic agent pirlimycin adenylate. Pharmacology. 1983;27(5):255-66.
- [6]. Sanchez MS, et al. Efficacy of tumor necrosis factor-alpha and antibiotics in therapy of experimental murine staphylococcal mastitis. Journal of dairy science. 1994 May;77(5):1259-66.
- [7]. Owens WE, et al. The postantibiotic effect of selected antibiotics on Staphylococcus aureus Newbould 305 from bovine intramammary infection. Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B. 1993 Dec;40(9-10):603-8.
