80-75-1
Chemical Structure
11alpha-Hydroxyprogesterone
- CAS No.: 80-75-1
- Formula:C21H30O3
- Molecular Weight:330.46
IUPAC Name: (8S,9S,10R,11R,13S,14S,17S)-17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: BFZHCUBIASXHPK-QJSKAATBSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](C[C@H]3O)([C@H](CC4)C(C)=O)C
Biological Activity: 11alpha-Hydroxyprogesterone is a naturally occurring steroid hormone and an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor. 11alpha-Hydroxyprogesterone decreases FAK protein expression and regulates epithelial-mesenchymal transition, cell migration, and cell invasion. 11alpha-Hydroxyprogesterone exhibits antiandrogenic and blood pressure-regulating activities. 11alpha-Hydroxyprogesterone is used in the research of breast cancer and malaria[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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11alpha-Hydroxyprogesterone | 99.53% | 11alpha-Hydroxyprogesterone is a naturally occurring steroid hormone and an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor. 11alpha-Hydroxyprogesterone decreases FAK protein expression and regulates epithelial-mesenchymal transition, cell migration, and cell invasion. 11alpha-Hydroxyprogesterone exhibits antiandrogenic and blood pressure-regulating activities. 11alpha-Hydroxyprogesterone is used in the research of breast cancer and malaria. | ||||||||||||||||||||
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References
- [1]. Kim N, et al. 11α-hydroxyprogesterone dampens lung metastasis via EMT modulation in PyMT-induced breast cancer murine model. Lab Anim Res. 2025 Oct 14;41(1):26.
- [2]. Kane NF, et al. Expression of the Fab enzymes (Fab I and Fab Z) from Plasmodium falciparum after exposure to Artemisia afra plant extracts and drugs screening. J Parasit Dis. 2023 Mar;47(1):46-58.
