8024-48-4
8024-48-4
Chemical Structure
Biological Activity: Casanthranol is a naturally derived, orally active mixture of anthraquinone glycosides that exhibits inhibitory activity against α-synuclein and bioactivities related to laxation. Casanthranol inhibits seed-induced α-synuclein fibrillation in cell-free systems and rescues preformed fibril-induced cytotoxicity in differentiated N2a cells. Casanthranol promotes intestinal transit in both the small and large intestines of mice with experimental constipation. Casanthranol can be used in research related to constipation[1][2].
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Casanthranol | Casanthranol is a naturally derived, orally active mixture of anthraquinone glycosides that exhibits inhibitory activity against α-synuclein and bioactivities related to laxation. Casanthranol inhibits seed-induced α-synuclein fibrillation in cell-free systems and rescues preformed fibril-induced cytotoxicity in differentiated N2a cells. Casanthranol promotes intestinal transit in both the small and large intestines of mice with experimental constipation. Casanthranol can be used in research related to constipation. | |||||||||||||||||||||
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References
- [1]. Nagata M, et al. Experimental constipation in mice induced by combined use of atropine and papaverine and the laxative effects of bisacodyl, casanthranol, magnesium sulfate, rhubarb, and thiamine derivatives. Kansai Medical University Journal, 1973, 25(3): 300-321.
- [2]. Braun AR, et al. Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein. ASN Neuro. 2023 Jan-Dec;15:17590914231184086. [Content Brief]
