84605-18-5
Chemical Structure
Cyclogalegenin
Synonym(s): Cyclogalegigenin
- CAS No.: 84605-18-5
- Formula:C30H50O5
- Molecular Weight:490.72
IUPAC Name: (2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyltetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthrene-4,7,9-triol
InChIKey: WENNXORDXYGDTP-ODAITAILSA-N
SMILES: O[C@H]1CC[C@@]2(C3)[C@]([C@@H](O)C[C@]4([H])[C@@]23CC[C@@]5(C)[C@@]4(C)C[C@H](O)[C@]5([H])[C@@]6(C)O[C@@H](C(C)(C)O)CC6)([H])C1(C)C
Biological Activity: Cyclogalegenin (Cyclogalegigenin) is a Plaur inhibitor with a Kd of 36.74 μM. Cyclogalegenin is a derivative of Cycloascauloside A. Cyclogalegenin inhibits the expression of Plaur mRNA and protein. Cyclogalegenin can be used for research on liver metastasis of colorectal cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyclogalegenin | 98.0% | Cyclogalegenin (Cyclogalegigenin) is a Plaur inhibitor with a Kd of 36.74 μM. Cyclogalegenin is a derivative of Cycloascauloside A. Cyclogalegenin inhibits the expression of Plaur mRNA and protein. Cyclogalegenin can be used for research on liver metastasis of colorectal cancer. | ||||||||||||||||||||
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Cyclogalegenin (Standard) | ≥98% | Cyclogalegenin (Standard) (Cyclogalegigenin (Standard)) is the analytical standard of Cyclogalegenin (HY-N0424). This product is intended for research and analytical applications. Cyclogalegenin (Cyclogalegigenin) is a Plaur inhibitor with a Kd of 36.74 μM. Cyclogalegenin is a derivative of Cycloascauloside A. Cyclogalegenin inhibits the expression of Plaur mRNA and protein. Cyclogalegenin can be used for research on liver metastasis of colorectal cancer. | ||||||||||||||||||||
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Similarity Score 1.00
HY-N1485Cycloastragenol -
Similarity Score 0.82
HY-160706HHQ16 -
Similarity Score 0.76
HY-N626220(S),24(R)-Ocotillol -
Similarity Score 0.76
HY-N17698Cyclogaleginoside B -
Similarity Score 0.74
HY-N9989Brachyoside B -
Similarity Score 0.73
HY-N7924Astragenol -
Similarity Score 0.71
HY-N10363Pixinol -
Similarity Score 0.71
HY-N19634Betulatriterpene C -
Similarity Score 0.67
HY-N18213-Epicabraleadiol -
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References
- [1]. Alaniya MD, et al. Triterpene glycosides of Astragalus and of their genins. X. Cyclogalegigenin from Astragalus galegiformis. Chemistry of Natural Compounds. 1983 May;19(3):314-20.
- [2]. Zhang Q, et al. Xian-Lian-Jie-Du Decoction suppresses colorectal cancer liver metastasis by inhibiting Plaur/Hbegf/EGFR-mediated actin cytoskeleton remodeling. Phytomedicine. 2026 Jun 23:158482.
- [3]. Alaniya MD, et al. Cycloascauloside A from Astragalus caucasicus leaves. Chemistry of natural compounds. 2006 Jul;42(4):445-8.
- [4]. Alaniya MD, et al. New cycloartane glycosides from Astragalus caucasicus and A. galegiformis. Chemistry of natural compounds. 2012 Nov;48(5):914-6.
