849335-07-5
849335-07-5
Chemical Structure
AC-099 hydrochloride
- CAS No.: 849335-07-5
- Formula:C9H9Cl2F3N4
- Molecular Weight:301.10
IUPAC Name: (E)-2-(4-chloro-3-(trifluoromethyl)benzylidene)hydrazine-1-carboximidamide hydrochloride
InChIKey: OMYOUCJVJYJITH-CQCNNJTASA-N
SMILES: FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F.[H]Cl
Biological Activity: AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AC-099 hydrochloride | 99.92% | AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats. | ||||||||||||||||||||
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References
- [1]. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. [Content Brief]
- [2]. Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. [Content Brief]
Keywords
